Article

Human neuromodulatory assembloids to study serotonin signaling and disease

2026-03-10

Abstract excerpt

Neuromodulators influence critical functions of the developing human brain and regulate behavioral states. Dysfunction of neuromodulatory systems is often involved in neuropsychiatric disease and many drugs for these conditions act on these signaling pathways. Recent advances in stem cell biology have made it possible to derive a wide range of cells across the developing human nervous system in regionalized organo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5cded5d6-2db9-5e30-8828-73dc6b186eec
DOI: 10.64898/2026.03.08.710407

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human neuromodulatory assembloids to study serotonin signaling and diseaseDOI 10.64898/2026.03.08.710407Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Human hindbrain organoids with segment-specific 5-HT neurons for motor modulationSemantic proximity Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Serotonergic innervation and cortical progenitor regulation in human brain assembloidsSemantic proximity Read

Brainstem organoids from human pluripotent stem cells contain neural crest populationSemantic proximity Read

Optimized derivation and functional characterization of 5-HT neurons from human embryonic stem cells.Semantic proximity Read

Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoidsSemantic proximity Read

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettesSemantic proximity Read

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screeningSemantic proximity Read

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.Semantic proximity Read

Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and MemorySemantic proximity Read

Generating human neural diversity with a multiplexed morphogen screen in organoidsSemantic proximity Read