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Article

Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Sept 2008

Tripathi Prem Prakash, Di Giovannantonio Luca Giovanni, Viegi Alessandro, Wurst Wolfgang, Simeone Antonio, Bozzi Yuri

Abstract excerpt

The homeobox-containing transcription factor Otx2 is crucially involved in fate determination of midbrain neurons. Mutant mice, in which Otx2 was conditionally inactivated by a Cre recombinase expressed under the transcriptional control of the Engrailed1 (En1) gene (En1(cre/+); Otx2(flox/flox)),...

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Identifiers

PMID: 18784307
DOI: 10.1523/JNEUROSCI.2208-08.2008
PMCID: PMC6670936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18784307-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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