Article

Serotonin system development and adult function are regulated by GDNF

2024-12-11

Abstract excerpt

Cognitive functions, neuropsychiatric disorders and behaviors from feeding to mood relate to the serotonin (5-hydroxytryptamine; 5-HT) system. We report that expression of glial cell line-derived neurotrophic factor (GDNF), a known potent stimulator of the brain dopamine system, correlates with serotonergic markers in humans, and increased GDNF defines a subset of psychiatric patients with a characteristic 5-HT-re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b81bc64b-012d-5800-b84f-e8d7f1a7fcfb
DOI: 10.1101/2024.12.11.627811

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serotonin system development and adult function are regulated by GDNFDOI 10.1101/2024.12.11.627811Read

Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation.Semantic proximity Read

Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?Semantic proximity Read

Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behaviorSemantic proximity Read

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandemSemantic proximity Read

Detection of serotonin and serotonin related gene reveals unique roles in human intestinal epithelial developmentSemantic proximity Read

New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.Semantic proximity Read

Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder.Semantic proximity Read

New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing BrainSemantic proximity Read

Serotonin, genetic variability, behaviour, and psychiatric disorders--a review.Semantic proximity Read

Understanding the role of serotonin in psychiatric diseasesSemantic proximity Read

Human hindbrain organoids with segment-specific 5-HT neurons for motor modulationSemantic proximity Read

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour.Semantic proximity Read