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Article

Intersection of population variation and autoimmunity genetics in human T cell activation.

Science (New York, N.Y.) - 12 Sept 2014

Ye Chun Jimmie, Feng Ting, Kwon Ho-Keun, Raj Towfique, Wilson Michael T, Asinovski Natasha, McCabe Cristin, Lee Michelle H, Frohlich Irene, Paik Hyun-il, Zaitlen Noah, Hacohen Nir, Stranger Barbara, De Jager Philip, Mathis Diane, Regev Aviv, Benoist Christophe

Abstract excerpt

T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans and its genetic or environmental roots. We analyzed gene expression in CD4(+) T cells during unbiased activation or in T helper 17 (T(H)17) conditions fr...

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Identifiers

PMID: 25214635
DOI: 10.1126/science.1254665
PMCID: PMC4751028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25214635-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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