Article
The genetic basis of autoimmunity seen through the lens of T cell functional traits.
Nature communications - 8 Feb 2024
Lagattuta Kaitlyn A, Park Hannah L, Rumker Laurie, Ishigaki Kazuyoshi, Nathan Aparna, Raychaudhuri Soumya
Abstract excerpt
Autoimmune disease heritability is enriched in T cell-specific regulatory regions of the genome. Modern-day T cell datasets now enable association studies between single nucleotide polymorphisms (SNPs) and a myriad of molecular phenotypes, including chromatin accessibility, gene expression, transcriptional programs, T cell antigen receptor (TCR) amino acid usage, and cell state abundances. Such studies have...
Topics
- Humans
- T-Lymphocytes
- Autoimmunity
- Quantitative Trait Loci
- Phenotype
- Polymorphism, Single Nucleotide
- Receptors, Antigen, T-Cell
- Autoimmune Diseases
- Genome-Wide Association Study