Article
The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.
Cell - 9 Apr 2015
Roederer Mario, Quaye Lydia, Mangino Massimo, Beddall Margaret H, Mahnke Yolanda, Chattopadhyay Pratip, Tosi Isabella, Napolitano Luca, Terranova Barberio Manuela, Menni Cristina, Villanova Federica, Di Meglio Paola, Spector Tim D, Nestle Frank O
Abstract excerpt
Despite recent discoveries of genetic variants associated with autoimmunity and infection, genetic control of the human immune system during homeostasis is poorly understood. We undertook a comprehensive immunophenotyping approach, analyzing 78,000 immune traits in 669 female twins. From the top 151 heritable traits (up to 96% heritable), we used replicated GWAS to obtain 297 SNP associations at 11 genetic loci,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.