Virus variation, escape from cytotoxic T lymphocytes and human retroviral persistence.

doi:10.1006/scdb.1998.0241

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Article

Virus variation, escape from cytotoxic T lymphocytes and human retroviral persistence.

Seminars in cell & developmental biology - 1 Jun 1998

Gould K G, Bangham C R

Abstract excerpt

Viruses use a variety of mechanisms to escape recognition by cytotoxic T lymphocytes (CTL). The available evidence suggests that the main mechanisms of CTL escape caused by viral sequence variation are loss of epitope binding to MHC molecules or altered recognition by T cell receptors. These type...

Topics

Genetic Variation
HIV-1
Human T-lymphotropic virus 1
Humans
RNA, Viral
T-Lymphocytes, Cytotoxic

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