Virus variation, escape from cytotoxic T lymphocytes and human retroviral persistence.

Abstract excerpt

Viruses use a variety of mechanisms to escape recognition by cytotoxic T lymphocytes (CTL). The available evidence suggests that the main mechanisms of CTL escape caused by viral sequence variation are loss of epitope binding to MHC molecules or altered recognition by T cell receptors. These types of mutations occur in both human immunodeficiency virus type 1 (HIV-1) and human T cell leukaemia virus type 1...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Variation
• Share to HIV-1
• Share to Human T-lymphotropic virus 1