Article
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.
The Journal of experimental medicine - 8 Jun 2009
Goonetilleke Nilu, Liu Michael K P, Salazar-Gonzalez Jesus F, Ferrari Guido, Giorgi Elena, Ganusov Vitaly V, Keele Brandon F, Learn Gerald H, Turnbull Emma L, Salazar Maria G, Weinhold Kent J, Moore Stephen, Letvin Norman, Haynes Barton F, Cohen Myron S, Hraber Peter, Bhattacharya Tanmoy, Borrow Persephone, Perelson Alan S, Hahn Beatrice H, Shaw George M, Korber Bette T, McMichael Andrew J
Abstract excerpt
Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1 proteome. A complete dissection was made of the primary HIV-1-specific T cell response induced in three acutely infected patients. Cellular assays, together with new algorithms which identify sites of positive selection in the virus genome, showed that...
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