Article
Immune-driven recombination and loss of control after HIV superinfection.
The Journal of experimental medicine - 4 Aug 2008
Streeck Hendrik, Li Bin, Poon Art F Y, Schneidewind Arne, Gladden Adrianne D, Power Karen A, Daskalakis Demetre, Bazner Suzane, Zuniga Rosario, Brander Christian, Rosenberg Eric S, Frost Simon D W, Altfeld Marcus, Allen Todd M
Abstract excerpt
After acute HIV infection, CD8(+) T cells are able to control viral replication to a set point. This control is often lost after superinfection, although the mechanism behind this remains unclear. In this study, we illustrate in an HLA-B27(+) subject that loss of viral control after HIV superinfection coincides with rapid recombination events within two narrow regions of Gag and Env. Screening for CD8(+) T cell...
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