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Article

HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression.

Scientific reports - 17 Jun 2015

Chang Chih-Hao, Kist Nicolaas C, Stuart Chester Tammy L, Sreenu Vattipally B, Herman Melissa, Luo Ma, Lunn Daniel, Bell John, Plummer Francis A, Ball T Blake, Katzourakis Aris, Iversen Astrid K N

Abstract excerpt

Cytotoxic T lymphocyte (CTL) responses against the HIV Gag protein are associated with lowering viremia; however, immune control is undermined by viral escape mutations. The rapid viral mutation rate is a key factor, but recombination may also contribute. We hypothesized that CTL responses drive the outgrowth of unique intra-patient HIV-recombinants (URFs) and examined gag sequences from a Kenyan sex worker...

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Share to gag Gene Products, Human Immunodeficiency Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Core Protein p24

Share to HIV Infections

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Share to Leukocytes, Mononuclear

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Share to Recombination, Genetic

Source

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Identifiers

PMID: 26082240
DOI: 10.1038/srep11253
PMCID: PMC4469978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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