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Article

Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.

Molecular cell - 22 Aug 2008

Tatarakis Antonis, Margaritis Thanasis, Martinez-Jimenez Celia Pilar, Kouskouti Antigone, Mohan William S, Haroniti Anna, Kafetzopoulos Dimitris, Tora Làszlò, Talianidis Iannis

Abstract excerpt

To study the in vivo role of TFIID in the transcriptional regulation of hepatic genes, we generated mice with liver-specific disruption of the TAF10 gene. Inactivation of TAF10 in hepatocytes resulted in the dissociation of TFIID into individual components. This correlated with the downregulation of most hepatocyte-specific genes during embryonic life and a defect in liver organogenesis. Unexpectedly, however,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18722179
DOI: 10.1016/j.molcel.2008.07.013

Genes

TAF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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