Article
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.
Development (Cambridge, England) - 1 Aug 2007
Fadloun Anas, Kobi Dominique, Pointud Jean-Christophe, Indra Arup Kumar, Teletin Marius, Bole-Feysot Christine, Testoni Barbara, Mantovani Roberto, Metzger Daniel, Mengus Gabrielle, Davidson Irwin
Abstract excerpt
The TAF4 subunit of transcription factor TFIID was inactivated in the basal keratinocytes of foetal and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced expression of the genes required for skin barrier function, leading to early neonatal death. By contrast, TAF4 inactivation in adult epidermis leads to extensive fur loss and an aberrant hair cycle characterised by a defective anagen...
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