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Article

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.

PLoS genetics - 1 Oct 2008

Landry Joseph, Sharov Alexei A, Piao Yulan, Sharova Lioudmila V, Xiao Hua, Southon Eileen, Matta Jennifer, Tessarollo Lino, Zhang Ying E, Ko Minoru S H, Kuehn Michael R, Yamaguchi Terry P, Wu Carl

Abstract excerpt

We have characterized the biological functions of the chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of NURF (Nucleosome Remodeling Factor) in a mammal. Bptf mutants manifest growth defects at the post-implantation stage and are reabsorbed by E8.5. Histological analyses of lineage markers show that Bptf(-/-) embryos implant but fail to establish a functional...

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Share to Antigens, Nuclear
Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Chromosomal Proteins, Non-Histone

Share to Embryonic Development

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Identifiers

PMID: 18974875
DOI: 10.1371/journal.pgen.1000241
PMCID: PMC2570622

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