Article
The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters.
The Journal of biological chemistry - 20 Apr 2001
Pare J F, Roy S, Galarneau L, Belanger L
Abstract excerpt
Fetoprotein transcription factor (FTF) is an orphan nuclear receptor that activates the alpha(1)-fetoprotein gene during early liver developmental growth. Here we sought to define better the position of FTF in transcriptional cascades leading to hepatic differentiation. The mouse FTF gene was isolated and assigned to chromosome 1 band E4 (one mFTF pseudogene was also found). Exon/intron mapping shows an mFTF gene...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Chromosome Mapping
- DNA-Binding Proteins
- Gene Expression Regulation
- Genetic Variation
- Genomic Library
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta