E2f8 mediates tumor suppression in postnatal liver development.

doi:10.1172/JCI85506

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Article

E2f8 mediates tumor suppression in postnatal liver development.

The Journal of clinical investigation - 1 Aug 2016

Kent Lindsey N, Rakijas Jessica B, Pandit Shusil K, Westendorp Bart, Chen Hui-Zi, Huntington Justin T, Tang Xing, Bae Sooin, Srivastava Arunima, Senapati Shantibhusan, Koivisto Christopher, Martin Chelsea K, Cuitino Maria C, Perez Miguel, Clouse Julian M, Chokshi Veda, Shinde Neelam, Kladney Raleigh, Sun Daokun, Perez-Castro Antonio, Matondo Ramadhan B, Nantasanti Sathidpak, Mokry Michal, Huang Kun, Machiraju Raghu, Fernandez Soledad, Rosol Thomas J, Coppola Vincenzo, Pohar Kamal S, Pipas James M, Schmidt Carl R, de Bruin Alain, Leone Gustavo

Abstract excerpt

E2F-mediated transcriptional repression of cell cycle-dependent gene expression is critical for the control of cellular proliferation, survival, and development. E2F signaling also interacts with transcriptional programs that are downstream of genetic predictors for cancer development, including hepatocellular carcinoma (HCC). Here, we evaluated the function of the atypical repressor genes E2f7 and E2f8 in adult...

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Identifiers

PMID: 27454291
DOI: 10.1172/JCI85506
PMCID: PMC4966321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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