Article

Deletion of NuRD component <i>Mta2</i> in nephron progenitor cells causes developmentally programmed FSGS

2023-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Low nephron endowment at birth is a risk factor for chronic kidney disease. The prevalence of this condition is increasing due to higher survival rates of preterm infants and children with multi- organ birth defect syndromes that affect the kidney and urinary tract. We created a mouse model of congenital low nephron number due to deletion of Mta2 in nephron progenitor cells. Mta2 is a core com...

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Literature Corpus work: 7302bc47-f9d9-5c94-903e-8cf4cbc8aa34
DOI: 10.1101/2023.10.18.562984

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