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Article

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.

Nature communications - 30 Mar 2016

Langer Diana, Martianov Igor, Alpern Daniel, Rhinn Muriel, Keime Céline, Dollé Pascal, Mengus Gabrielle, Davidson Irwin

Abstract excerpt

TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 where primary germ layers and many embryonic structures are identified showing Taf4 is dispensable for their specification. In contrast, Taf4 is required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27026076
DOI: 10.1038/ncomms11063
PMCID: PMC4820908

Genes

TAF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.PMID 27026076Read ↗

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TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis.Semantic proximity Read ↗

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The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.Semantic proximity Read ↗

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TAF7L REGULATES EARLY STAGES OF MALE GERM CELL DEVELOPMENTSemantic proximity Read ↗

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