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Article

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.

Nature communications - 11 Sept 2014

Chan Ying Wai, West Stephen C

Abstract excerpt

Holliday junction (HJ) resolvases are necessary for the processing of persistent recombination intermediates before cell division. Their actions, however, need to be restricted to the late stages of the cell cycle to avoid the inappropriate cleavage of replication intermediates. Control of the yeast HJ resolvase, Yen1, involves phosphorylation changes that modulate its catalytic activity and nuclear import. Here,...

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Identifiers

PMID: 25209024
DOI: 10.1038/ncomms5844
PMCID: PMC4172962

Genes

GEN1
BLM
MUS81
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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