Article
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.
Nucleic acids research - 1 Apr 2010
Lorenz Alexander, West Stephen C, Whitby Matthew C
Abstract excerpt
A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this function in human cells is presently unknown, recent studies led to the identification of the XPG-family endonuclease GEN1 that promotes Holliday junction resolution in vitro, suggesting that it may perform a related function in vivo. Here, we show that...
Topics
- DNA Helicases
- DNA-Binding Proteins
- Endonucleases
- Genetic Complementation Test
- Holliday Junction Resolvases
- Humans
- Meiosis
- Mutagens
- Mutation
- Phenotype
- Recombination, Genetic