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Article

Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.

Molecular cell - 10 Apr 2014

Blanco Miguel G, Matos Joao, West Stephen C

Abstract excerpt

The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24631285
DOI: 10.1016/j.molcel.2014.02.011
PMCID: PMC3988869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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