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Article

Holliday junctions in the eukaryotic nucleus: resolution in sight?

Trends in biochemical sciences - 1 Oct 2003

Heyer Wolf Dietrich, Ehmsen Kirk T, Solinger Jachen A

Abstract excerpt

The Holliday junction is a key recombination intermediate whose resolution generates crossovers. Interplay between recombination, repair and replication has moved the Holliday junction to the center stage of nuclear DNA metabolism. Holliday junction resolvases in the eukaryotic nucleus have long eluded identification. The endonucleases Mus81/Mms4-Eme1 and XPF-MEI-9/MUS312 are structurally related to the archaeal...

Topics

Alleles
Animals
Bacterial Proteins
Cell Nucleus
DNA Repair
DNA Replication
DNA-Binding Proteins
Humans
Nucleic Acid Conformation
Phenotype
Recombination, Genetic
Substrate Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14559184
DOI: 10.1016/j.tibs.2003.08.011

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Holliday junctions in the eukaryotic nucleus: resolution in sight?PMID 14559184Read ↗

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