Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.

doi:10.1016/j.cell.2012.03.023

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Article

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.

Cell - 13 Apr 2012

Zakharyevich Kseniya, Tang Shangming, Ma Yunmei, Hunter Neil

Abstract excerpt

At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-Mms4(EME1), Slx1-Slx4(BTBD12), and Yen1(GEN1). Using physical monitoring of recombination during...

Topics

Crossing Over, Genetic
DNA, Cruciform
Endodeoxyribonucleases
Holliday Junction Resolvases
Meiosis
Mutation
RecQ Helicases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 22500800
DOI: 10.1016/j.cell.2012.03.023
PMCID: PMC3377385

Genes

EME1
GEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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