Article
The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.
Molecular cell - 10 Apr 2014
Eissler Christie L, Mazón Gerard, Powers Brendan L, Savinov Sergey N, Symington Lorraine S, Hall Mark C
Abstract excerpt
Faithful genome transmission during cell division requires precise, coordinated action of DNA metabolic enzymes, including proteins responsible for DNA damage detection and repair. Dynamic phosphorylation plays an important role in controlling repair enzymes during the DNA damage response (DDR). Cdc14 phosphatases oppose cyclin-dependent kinase (Cdk) phosphorylation and have been implicated in the DDR in several...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.