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Article

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.

Molecular cell - 16 Jun 2016

Spies Julian, Waizenegger Anja, Barton Olivia, Sürder Michael, Wright William D, Heyer Wolf-Dietrich, Löbrich Markus

Abstract excerpt

Never-in-mitosis A-related kinase 1 (Nek1) has established roles in apoptosis and cell cycle regulation. We show that human Nek1 regulates homologous recombination (HR) by phosphorylating Rad54 at Ser572 in late G2 phase. Nek1 deficiency as well as expression of unphosphorylatable Rad54 (Rad54-S572A) cause unresolved Rad51 foci and confer a defect in HR. Phospho-mimic Rad54 (Rad54-S572E), in contrast, promotes HR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27264870
DOI: 10.1016/j.molcel.2016.04.032
PMCID: PMC5503685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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