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Article

Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

The Journal of biological chemistry - 24 Oct 2014

Humphrey Rohan K, Ray Anamika, Gonuguntla Sumati, Hao Ergeng, Jhala Ulupi S

Abstract excerpt

Disabling cellular defense mechanisms is essential for induction of apoptosis. We have previously shown that cytokine-mediated activation of the MAP3K MLK3 stabilizes TRB3 protein levels to inhibit AKT and compromise beta cell survival. Here, we show that genetic deletion of TRB3 results in basal...

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Identifiers

PMID: 25204656
DOI: 10.1074/jbc.M114.575613
PMCID: PMC4208007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25204656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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