Article

Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell death

2020-11-25

Abstract excerpt

<h4>ABSTRACT</h4> A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely failed to achieve robust clinical success. The molecular mechanisms preventing the activation of mitogenic signaling pathways from maintaining func...

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Literature Corpus work: 0d2a006f-9730-5b26-8b0a-7f33112ed440
DOI: 10.1101/2020.11.24.380279

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