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Article

In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.

PloS one - 1 Jan 2012

Coppola Antonina, Tomasello Laura, Pizzolanti Giuseppe, Pucci-Minafra Ida, Albanese Nadia, Di Cara Gianluca, Cancemi Patrizia, Pitrone Maria, Bommarito Alessandra, Carissimi Elvira, Zito Giovanni, Criscimanna Angela, Galluzzo Aldo, Giordano Carla

Abstract excerpt

Type 1 diabetes mellitus (T1DM) is caused by the selective destruction of insulin-producing β-cells. This process is mediated by cells of the immune system through release of nitric oxide, free radicals and pro-inflammatory cytokines, which induce a complex network of intracellular signalling cas...

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Identifiers

PMID: 22393382
DOI: 10.1371/journal.pone.0032109
PMCID: PMC3290556

Genes

SUMO4
PDX1
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22393382-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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