Article
Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2014
Mingueneau Michael, Krishnaswamy Smita, Spitzer Matthew H, Bendall Sean C, Stone Erica L, Hedrick Stephen M, Pe'er Dana, Mathis Diane, Nolan Garry P, Benoist Christophe
Abstract excerpt
Signaling from the T-cell receptor (TCR) conditions T-cell differentiation and activation, requiring exquisite sensitivity and discrimination. Using mass cytometry, a high-dimensional technique that can probe multiple signaling nodes at the single-cell level, we interrogate TCR signaling dynamics in control C57BL/6 and autoimmunity-prone nonobese diabetic (NOD) mice, which show ineffective ERK activation after...
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