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Article

RIPK3-mediated inflammation is a conserved β cell response to ER stress

18 Dec 2020

Abstract excerpt

expression in vitro. Furthermore, in human islets grafted in hyperglycemic mice, a marked increase in ER stress, RIPK3, and NF-kB activation in β cells were accompanied with murine macrophage infiltration. Thus, RIPK3-mediated induction of proinflammatory mediators is a conserved, previously unrecognized β cell response to metabolic stress and a mediator of the ensuing islet inflammation.

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PMID: 33355143
DOI: 10.1126/sciadv.abd7272

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