Article
CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.
Cellular immunology - 1 Jan 2011
Reiné Jesús, Busto Elena M, Muñoz-Ruiz Miguel, Rossi Nineth E, Rodríguez-Fernández José L, Martínez-Naves Eduardo, Regueiro José R, Recio María J
Abstract excerpt
Antigen recognition by T-lymphocytes through the T-cell antigen receptor, TCR-CD3, is a central event in the initiation of an immune response. CD3 proteins may have redundant as well as specific contributions to the intracellular propagation of TCR-mediated signals. However, to date, the relative role that each CD3 chain plays in signaling is controversial. In order to examine the roles of CD3γ chain in TCR...
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