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Article

TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.

Human molecular genetics - 1 Sept 2014

Han Bing, Luo Hongyu, Raelson John, Huang Jie, Li Yun, Tremblay Johanne, Hu Bing, Qi Shijie, Wu Jiangping

Abstract excerpt

Transforming growth factor beta-induced (TGFBI/βIG-H3), also known as βig-H3, is a protein inducible by TGFβ1 and secreted by many cell types. It binds to collagen, forms part of the extracellular matrix and interacts with integrins on the cell surface. Recombinant TGFBI and transgenic TGFBI overexpression can promote both islet survival and function. In this study, we generated TGFBI KO mice and further assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24728038
DOI: 10.1093/hmg/ddu173
PMCID: PMC4119410

Genes

TGFBI
RPS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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