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Article

X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

Annals of surgery - 1 Oct 2014

Sperry Jason L, Zolin Samuel, Zuckerbraun Brian S, Vodovotz Yoram, Namas Rami, Neal Matthew D, Ferrell Robert E, Rosengart Matthew R, Peitzman Andrew B, Billiar Timothy R

Abstract excerpt

OBJECTIVE(S): Clinical research characterizing the mechanisms responsible for sex-based outcome differences postinjury remain conflicting. We sought to characterize an X chromosome-linked IRAK-1 (IL-1 receptor-associated kinase) polymorphism as an alternative mechanism responsible for sex differences postinjury. IRAK-1 is key intermediate in the toll-like receptor (TLR) pathway thought to drive inflammation...

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Share to Chromosomes, Human, X
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

Share to Multiple Organ Failure

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Share to Sepsis

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Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 25203887
DOI: 10.1097/SLA.0000000000000918
PMCID: PMC4159729

Genes

IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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