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RELATIONSHIP BETWEEN TRPM4 RS8104571 GENOTYPE, CIRCULATING TRPM4 AND SUR1, AND CLINICAL OUTCOME FOLLOWING TRAUMATIC BRAIN INJURY.

Shock (Augusta, Ga.) - 1 Jan 2025

Krocker Joseph D, Cotton Madeline E, Ashley Janet R, Schriner Jacob B, Osborn Baron K, Wang Yao-Wei Willa, Cox Charles S, Wade Charles E

Abstract excerpt

ABSTRACT: The variant single nucleotide polymorphism rs8104571 has been associated with poor outcomes following traumatic brain injury (TBI) and is most prevalent in those of African ancestry. This single nucleotide polymorphism (SNP) resides within a gene coding for the TRPM4 protein, which complexes with SUR1 protein to create a transmembrane ion channel and is believed to contribute to cellular swelling and...

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PMID: 39227352
DOI: 10.1097/SHK.0000000000002468

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