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INTERACTIONS BETWEEN BIOLOGICAL SEX AND THE X-LINKED VARIANT IRAK1 HAPLOTYPE IN MODULATING CLINICAL OUTCOME AND CELLULAR PHENOTYPES AFTER TRAUMA.

Shock (Augusta, Ga.) - 1 Aug 2022

Qin Yong, Livingston David H, Spolarics Zoltan

Abstract excerpt

ABSTRACT: Sex-related outcome differences in trauma remain controversial. The mechanisms causing sex-biased outcomes are likely to have hormonal and genetic components, in which X-linked genetic polymorphisms may play distinct roles because of X-linked inheritance, hemizygosity in males, and X chromosome mosaicism in females. The study aimed to elucidate the contribution of biological sex and the common X-linked...

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PMID: 35953456
DOI: 10.1097/SHK.0000000000001966

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