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Article

Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.

Critical care medicine - 1 Oct 2008

Christie Jason D, Ma Shwu-Fan, Aplenc Richard, Li Mingyao, Lanken Paul N, Shah Chirag V, Fuchs Barry, Albelda Steven M, Flores Carlos, Garcia Joe G N

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms in the myosin light chain kinase (MYLK) gene have been implicated in the risk of sepsis-related acute lung injury and asthma. MYLK encodes protein isoforms involved in multiple components of the inflammatory response, including apoptosis, vascular permeability, and leukocyte diapedesis. We tested the association of MYLK gene variation in the development of acute lung...

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Source

Identifiers

PMID: 18828194
DOI: 10.1097/ccm.0b013e318186b843

Genes

MYLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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