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Article

Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis.

American journal of respiratory and critical care medicine - 15 Jun 2006

Arcaroli John, Silva Eliezer, Maloney James P, He Qianbin, Svetkauskaite Daiva, Murphy James R, Abraham Edward

Abstract excerpt

RATIONALE: The IL-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-kappaB, a critical event in the transcriptional regulation of many sepsis-associated proinflammatory mediators. There are two haplotypes for the IRAK-1 gene in Caucasians, with the variant haplotype consisting of five intron single-nucleotide polymorphisms (SNPs) and three exon...

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Source

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Identifiers

PMID: 16528020
DOI: 10.1164/rccm.200603-341OC
PMCID: PMC2662973

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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