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Article

Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype.

Inflammation - 1 Feb 2020

Morcillo Patrick, Qin Yong, Peña Geber, Mosenthal Anne C, Livingston David H, Spolarics Zoltan

Abstract excerpt

Random X chromosome (ChrX) inactivation and consequent cellular mosaicism for the active ChrXs in white blood cells (WBCs) is unique to females and may contribute to sex-biased modulation of the innate immune response. Polymorphic differences between the two parental ChrXs may result in ChrX skewing of circulating WBCs (ChrX inactivation-ratio (XCI) > 3) driven by differences in stem cell selection and activity...

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Share to Chromosomes, Human, X
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

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Identifiers

PMID: 31748848
DOI: 10.1007/s10753-019-01127-6

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