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Article

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

24 Aug 2013

Abstract excerpt

In Brief Objective: Our objective was to execute a prospective cohort study to determine relationships between plasma mtDNA DAMP levels and the occurrence of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mortality. Background: Mitochondrial DNA damage-associated molecular patterns (DAMPs) accumulate in the circulation after severe injury. Observations in animal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23979273
DOI: 10.1097/sla.0b013e3182a4ea46

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