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Article

Genetic predisposition for a compromised immune system after multiple trauma.

Shock (Augusta, Ga.) - 1 Dec 2005

Hildebrand Frank, Pape Hans-Christoph, van Griensven Martijn, Meier Sven, Hasenkamp Sandra, Krettek Christian, Stuhrmann Manfred

Abstract excerpt

Severe trauma induces sustained changes of the immune response, which are thought to be related to secondary organ dysfunction. Despite a similar injury severity, the extent of the inflammatory response may vary between polytraumatized patients. It is unclear whether inflammatory variability is associated with genetic variations. In this prospective cohort study, patients were included when the following criteria...

Topics

Adolescent
Adult
Cytokines
Female
Genetic Predisposition to Disease
Humans
Inflammation
Male
Middle Aged
Multiple Trauma
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Predictive Value of Tests

Systemic Inflammatory Response Syndrome

Source

Identifiers

PMID: 16317381
DOI: 10.1097/01.shk.0000184212.97488.4e

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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