Article
An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma.
Shock (Augusta, Ga.) - 1 Mar 2018
Schimunek Lukas, Namas Rami A, Yin Jinling, Liu Dongmei, Barclay Derek, El-Dehaibi Fayten, Abboud Andrew, Lindberg Haley, Zamora Ruben, Billiar Timothy R, Vodovotz Yoram
Abstract excerpt
Trauma is the leading cause of death worldwide for individuals under the age of 55. Interpatient genomic differences, in the form of candidate single-nucleotide polymorphisms (SNPs), have been associated previously with adverse outcomes after trauma. However, the utility of these SNPs to predict outcomes based on a meaningful endpoint such as survival is as yet undefined. We hypothesized that specific SNP...
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