Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury.

Journal of burn care & research : official publication of the American Burn Association - 1 Jan 2000

Barber Robert C, Chang Ling-Yu E, Lemaire Susan M, Burris Agnes, Purdue Gary F, Hunt John L, Arnoldo Brett D, Horton Jureta W

Abstract excerpt

Replication of statistically significant associations between single nucleotide polymorphisms (SNPs) and disease phenotypes has been problematic. One reason for conflicting observations may be failure to consider confounding factors, including gene-gene (epistatic) interactions. Our experience with the insertion/deletion polymorphism at -688 in the promoter region of plasminogen activator inhibitor (PAI-1) seems...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Burns
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Infections

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

Share to Risk Factors

Share to Wounds and Injuries

Source

Identifiers

PMID: 18182917
DOI: 10.1097/BCR.0b013e31815f59f4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury.PMID 18182917Read ↗

Tumor necrosis factor gene variation and the risk of mortality after burn injury: a cohort study.Semantic proximity Read ↗

Pathway genetic load allows simultaneous evaluation of multiple genetic associations.Semantic proximity Read ↗

Detecting genetic predisposition for complicated clinical outcomes after burn injury.Semantic proximity Read ↗

CD14-159 C allele is associated with increased risk of mortality after burn injury.Semantic proximity Read ↗

Searching for alleles associated with complicated outcomes after burn injury.Semantic proximity Read ↗

IL-10 polymorphism associated with decreased risk for mortality after burn injury.Semantic proximity Read ↗

Innate immunity SNPs are associated with risk for severe sepsis after burn injury.Semantic proximity Read ↗

Genetic predisposition for a compromised immune system after multiple trauma.Semantic proximity Read ↗

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and SepsisSemantic proximity Read ↗

SNP-set analysis replicates acute lung injury genetic risk factors.Semantic proximity Read ↗

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma.Semantic proximity Read ↗

The genetic predisposition to adverse outcome after trauma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.