Article
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.
Aging cell - 1 Apr 2013
Beekman Marian, Blanché Hélène, Perola Markus, Hervonen Anti, Bezrukov Vladyslav, Sikora Ewa, Flachsbart Friederike, Christiansen Lene, De Craen Anton J M, Kirkwood Tom B L, Rea Irene Maeve, Poulain Michel, Robine Jean-Marie, Valensin Silvana, Stazi Maria Antonietta, Passarino Giuseppe, Deiana Luca, Gonos Efstathios S, Paternoster Lavinia, Sørensen Thorkild I A, Tan Qihua, Helmer Quinta, van den Akker Erik B, Deelen Joris, Martella Francesca, Cordell Heather J, Ayers Kristin L, Vaupel James W, Törnwall Outi, Johnson Thomas E, Schreiber Stefan, Lathrop Mark, Skytthe Axel, Westendorp Rudi G J, Christensen Kaare, Gampe Jutta, Nebel Almut, Houwing-Duistermaat Jeanine J, Slagboom Pieternella Eline, Franceschi Claudio
Abstract excerpt
Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy...
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