Article
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.
BMC geriatrics - 9 Apr 2016
Druley Todd E, Wang Lihua, Lin Shiow J, Lee Joseph H, Zhang Qunyuan, Daw E Warwick, Abel Haley J, Chasnoff Sara E, Ramos Enrique I, Levinson Benjamin T, Thyagarajan Bharat, Newman Anne B, Christensen Kaare, Mayeux Richard, Province Michael A
Abstract excerpt
BACKGROUND: The Long Life Family Study (LLFS) is an international study to identify the genetic components of various healthy aging phenotypes. We hypothesized that pedigree-specific rare variants at longevity-associated genes could have a similar functional impact on healthy phenotypes. METHODS: We performed custom hybridization capture sequencing to identify the functional variants in 464 candidate genes for...
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