Article
A genome-wide association study of aging.
Neurobiology of aging - 1 Nov 2011
Walter Stefan, Atzmon Gil, Demerath Ellen W, Garcia Melissa E, Kaplan Robert C, Kumari Meena, Lunetta Kathryn L, Milaneschi Yuri, Tanaka Toshiko, Tranah Gregory J, Völker Uwe, Yu Lei, Arnold Alice, Benjamin Emelia J, Biffar Reiner, Buchman Aron S, Boerwinkle Eric, Couper David, De Jager Philip L, Evans Denis A, Harris Tamara B, Hoffmann Wolfgang, Hofman Albert, Karasik David, Kiel Douglas P, Kocher Thomas, Kuningas Maris, Launer Lenore J, Lohman Kurt K, Lutsey Pamela L, Mackenbach Johan, Marciante Kristin, Psaty Bruce M, Reiman Eric M, Rotter Jerome I, Seshadri Sudha, Shardell Michelle D, Smith Albert V, van Duijn Cornelia, Walston Jeremy, Zillikens M Carola, Bandinelli Stefania, Baumeister Sebastian E, Bennett David A, Ferrucci Luigi, Gudnason Vilmundur, Kivimaki Mika, Liu Yongmei, Murabito Joanne M, Newman Anne B, Tiemeier Henning, Franceschini Nora
Abstract excerpt
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either...
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