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Article

Calreticulin affects focal contact-dependent but not close contact-dependent cell-substratum adhesion.

The Journal of biological chemistry - 21 May 1999

Fadel M P, Dziak E, Lo C M, Ferrier J, Mesaeli N, Michalak M, Opas M

Abstract excerpt

We used two cell lines expressing fast (RPEfast) and slow (RPEslow) attachment kinetics to investigate mechanisms of cell-substratum adhesion. We show that the abundance of a cytoskeletal protein, vinculin, is dramatically decreased in RPEfast cells. This coincides with the diminished expression level of an endoplasmic reticulum chaperone, calreticulin. Both protein and mRNA levels for calreticulin and vinculin...

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Source

Identifiers

PMID: 10329714
DOI: 10.1074/jbc.274.21.15085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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