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Article

In situ mechanotransduction via vinculin regulates stem cell differentiation

29 Jul 2013

Abstract excerpt

Human mesenchymal stem cell (hMSC) proliferation, migration, and differentiation have all been linked to extracellular matrix stiffness, yet the signaling pathway(s) that are necessary for mechanotransduction remain unproven. Vinculin has been implicated as a mechanosensor in vitro, but here we demonstrate its ability to also regulate stem cell behavior, including hMSC differentiation. RNA interference-mediated...

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PMID: 23897765
DOI: 10.1002/stem.1490

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