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Vinculin Force Sensor Detects Tumor-Osteocyte Interactions

4 Apr 2019

Abstract excerpt

This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin tension sensor to quantitatively evaluate the force in focal adhesions of the tumor cell. Tumor...

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PMID: 30948840
DOI: 10.1038/s41598-019-42132-x

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