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Article

Effects of mutations in multiple Ethionamide-resistance-associated genes among Mycobacterium tuberculosis clinical isolates from China.

Frontiers in cellular and infection microbiology - 1 Jan 2025

Wang Wei, Bo Xiang-Long, Li Ma-Chao, Lin Shi-Qiang, Liu Hai-Can, Fan Xue-Ting, Zhao Xiu-Qin, Wan Kang-Lin, Zhao Li-Li

Abstract excerpt

Objectives: The growing burden of drug-resistant tuberculosis (TB) constitutes a major public health challenge. Ethionamide (ETH), a second-line anti-TB drug, plays an important role in the treatment of multidrug-resistant tuberculosis (MDR-TB). However, the molecular mechanisms underlying ETH resistance remain incompletely elucidated. Thus, this study aimed to evaluate the effects of mutations in ETH...

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Identifiers

PMID: 41625156
DOI: 10.3389/fcimb.2025.1725219
PMCID: PMC12855482

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