Article
Molecular Analysis of the embCAB Locus and embR Gene Involved in Ethambutol Resistance in Clinical Isolates of Mycobacterium tuberculosis in France.
Antimicrobial agents and chemotherapy - 1 Aug 2015
Brossier Florence, Sougakoff Wladimir, Bernard Christine, Petrou Matthieu, Adeyema Karine, Pham Anne, Amy de la Breteque Diane, Vallet Marine, Jarlier Vincent, Sola Christophe, Veziris Nicolas
Abstract excerpt
Modification of codon 306 in embB is regarded as the main mechanism leading to ethambutol (ETB) resistance in clinical isolates of Mycobacterium tuberculosis. However, numerous mutations elsewhere in the embCAB locus and in embR, a putative transcriptional activator of this locus, have been reported to be involved in ETB resistance. Here, we investigated the diversity of nucleotide variations observed in embCAB...
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