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Article

A regulatory polymorphism in HAVCR2 modulates susceptibility to HIV-1 infection.

PloS one - 1 Jan 2014

Sironi Manuela, Biasin Mara, Gnudi Federica, Cagliani Rachele, Saulle Irma, Forni Diego, Rainone Veronica, Trabattoni Daria, Garziano Micaela, Mazzotta Francesco, Real Luis Miguel, Rivero-Juarez Antonio, Caruz Antonio, Lo Caputo Sergio, Clerici Mario

Abstract excerpt

The HAVCR2 gene encodes TIM-3, an immunoglobulin superfamily member expressed by exhausted CD8+ T cells during chronic viral infection. We investigated whether genetic variation at HAVCR2 modulates the susceptibility to HIV-1 acquisition; specifically we focused on a 3' UTR variant (rs4704846, A/G) that represents a natural selection target. We genotyped rs4704846 in three independent cohorts of HIV-1 exposed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies
Share to Genetic Predisposition to Disease
Share to Hepatitis A Virus Cellular Receptor 2
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Share to Linkage Disequilibrium
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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 25180498
DOI: 10.1371/journal.pone.0106442
PMCID: PMC4152274

Genes

HAVCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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